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| QUANTUM YIELDS OF SINGLET OXYGEN (O 2(1 D g)) PRODUCTION (F D) BY THE PHOTOSENSITIZING 2-ARYLPROPIONIC ACIDS IN FOUR-COMPONENT ANIONIC MICROEMULSIONS.
Luis A. Martínez, André M. Braun and E. Oliveros Lehrstuhl für Umweltmeßtechnik, Engler-Bunte-Institut, Universität Karlsruhe, D-76128 Karlsruhe, Germany
ABSTRACT: We have measured the quantum yields (F D) of singlet oxygen (1 O 2) production by a series of photosensitizing anti-inflammatory agents monitoring the 1 O 2 luminescence at 1270 nm upon excitation of the drugs. The experiments have been carried out in selected four-component anionic microemulsions under air equilibrated conditions. We have assessed the influence of the medium on the efficiency of 1 O 2 production, since microheterogeneous systems may be employed as simplest models to mimic more complicated biological microenvironments. Our result have shown that F D is highly influenced by the medium and is enhanced in microheterogeneous systems, some anti-inflammatory drugs being very efficient 1 O 2 sensitizers (F D app of tiaprofenic acid ~ 0.86 and F D app of suprofen ~ 0.70). The location of the drugs in the interfacial region together with their high value of F D indicate that type II reactions may play a significant role in the overall sensitization process in biological microenvironments.