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Effects of Strutural Stability on the Adsorption of Bacteriophage T4 Lysozyme Johan Fröberg: Physical Chemistry, Dept. of Chemistry, KTH I am doing my graduate work in the Surface Force Group which is a cooperation between the dept of Physical Chemistry at KTH, and the Institute for Surface Chemistry both in Stockholm. Our main experimental method is an interferometric technique which gives a direct measure of the interaction between two solid surfaces as a function of their separation with Angstrom resolution. The analysis is done within the framework of long-range forces such as electrostatic double layer repulsion and van der Waals attraction, as well as steric or structural forces, due interaction between adsorbed layers, and hydrophobic interactions. My objective is to study how the adsorption of biomolecules, mainly proteins, alters the observed interactions. The direct measure of the separation, with a known zero contact between bare surfaces, also make an analysis of the structure of the adsorbed layer possible. Different proteins and different properties of the protein give a wide variety of effects. Among the more important seem the structural stability to be. My last study therefore concerns a wild type protein and one synthetic variant differing in structural stability, which allow us to study the importance of different folding energies. In order to complement I have also used other surface sensitive techniques, e.g., ellipsometry, and written some programs for the theoretical analysis fo the results. ## Back to the list of abstracts