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An Analytical Approach to Protein Design. Skorobogatiy Maksim, Hong Guo & Martin Zuckermann. Department of Physics McGill University 3600 Rue University Montreal, Quebec H3A--2T8 Canada We have considered the problem of protein design analytically based on a model where the contact energy between amino acid residues is fitted phenomenologically using the Miyazawa--Jernigan matrix. Due to the simple form of the contact energy function, an analytical prescription is found which allows us to design energetically stable sequences for fixed amino acid residues compositions and target structures. The theoretically obtained sequences are compared with real proteins and good correspondence is obtained. Our calculation also allows us to comment on the kinetics of protein folding. In particular we examine the problem of the existence of a funnel-like energy landscape for the folding kinetics. The existance of hedgehog like landscape was also found for systems in which dynamics is implemented with a set of local moves. ## Back to the list of abstracts