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Paul Heelis Education. Ph.D. in Photochemistry 1978, B.Sc. (Hons) Chemistry, 1974 (Salford University, UK) Position. Reader in Chemistry School of Science and Technology The North East Wales Institute, Mold Rd, Wrexham, LL11 2AW, UK Research interests - Photochemistry, Photobiology, Radiation Chemistry, DNA repair enzymes, Drug induced phototoxicity, Molecular modelling Grants awarded from SERC, NATO, The Royal Society, The British Council, Burroughs-Wellcome, Nuffield Foundation, European Community, The Wellcome Trust. Invited speaker at 1997 European Society of Photobiology meeting, Italy; 18th International Conference on Photochemistry, Warsaw; 1996 Gordon Research Conference on Electron Transfer; 1996 International Photobiology meeting Vienna; 1995 Symposium on Physical Organic Chemistry, Poznan, Poland; 1994 French Photobiology Annual Meeting; 1993 Italian Photobiology Annual Meeting (Plenary lecture); Secretary to organising committee for the 1995 European Society for photobiology, Cambridge. Membership of societies. American Society for Photobiology European Photochemical Association British Photobiological Society European Society of Photobiology Reviews The photophysical and photochemical properties of flavins (isoalloxazines) P.F. Heelis, Chemical Society Reviews (1982), 112, 15. The Photochemistry of flavins, P. F. Heelis, (1991 ) in "Chemistry and biochemistry of flavoenzymes", edited by F. Muller,pp 171 published by C.R.C. Press. The photorepair of Pyrimidine dimers by DNA photolyase and model systems, P.F.Heelis, S-T.Kim, T.Okamura, and A.Sancar J.Photochem. Photobiol. (1993)17, 219-228 The photoenzymic repair of DNA: a chemist's perspective, Paul F. Heelis, Rosemarie F. Hartman and Seth D. Rose, Chemical Society Reviews, 1995, p289 Energy and Electron Transfer Processes in Flavoprotein-Mediated DNA Repair, Paul F. Heelis, Rosemarie F. Hartman and Seth D. Rose, J.Photochem. Photobiol.A. 1996, 95, 89-98 The role of Tryptophans in substrate binding and catalysis by DNA photolyase, S-T, Kim, P.F.Heelis and A.Sancar, Methods in Enzymology, 1995, 258, 319-343. Research Articles A laser photolysis study of the nature of flavin mononucleotide triplet states and the reaction of the neutral form with amino acids; P. F. Heelis, B. J. Parsons, G. O. Phillips and J. F. McKellar. Photochem.Photobiol., (1978), 28, 169-173. The photoreduction of flavins by amino acids and EDTA. A continuous and flash photolysis study; P. F. Heelis, B. J. Parsons, G. O. Phillips and J. F. McKellar, Ibid., (1979), 30, 343-347. Flavin pigments embedded in lipid matricies: A spectroscopic and photochemical investigation. P. F. Heelis, B. J. Parsons, G. O. Phillips, C. Barghigiani, G. Colombetti, F. Lenci and J. F. McKellar, Ibid. (1979), 30, 507-512. The pH dependence of the reactions of the flavin triplet states with amino acids. A laser flash photolysis study; P. F. Heelis, B. J. Parsons and G. O. Phillips, Biochim.Biophys.Acta., (1979), 587, 455-462. The photoreduction of flavins - a laser flash photolysis study; P. F. Heelis and G. O. Phillips. Photobiochemistry and Photobiophysics, (1979), 1, 63-70. The photodegradation of formylmethylflavin - a continuous and flash photolysis study; P. F. Heelis, G. O. Phillips, I. Ahmad and H.D.C. Rapson, Photobiochemistry and Photobiophysics (1979), 1, 125-130. The alkaline hydrolysis of formyl-methyl flavin - a kinetic and analytical study; I. Ahmad, H.D.C.Rapson, P. F. Heelis, G. O. Phillips, J.Org.Chem. (1980), 45, 171-176. The stigma of Euglena gracilis - an investigation for the possible occurrence of caroteno proteins and nucleic acids; D. V. Heelis, P. F. Heelis, G. O. Phillips, Cytobios (1980), 29, 135-143. The flavin sensitised photooxidation of ascorbic acid - a continuous and flash photolysis study; P. F. Heelis, B. J. Parsons, G. O. Phillips and J. F. McKellar. Photochem.Photobiol. (1981), 33, 7-13. Does the stigma of Euglena Gracilis play an active role in the photoreception process of this organism? A photochemical investigation of isolated stigmata, D. V. Heelis, P. F. Heelis, F. Bradshaw and G. O. Phillips. Photobiochem.Photobiophys., (1981), 3, 77-81. The one-electron reduction of lumichrome and its methyl derivatives in aqueous solution: A pulse radiolysis study; P. F. Heelis, B. J. Parsons, G. O. Phillips, E. J. Land and A. J. Swallow, J. Phys. Chem. (1982), 86, 5169-5174. The acid-base and redox properties of the one-electron reduced forms of lumichrome derivatives in aqueous solution; P. F. Heelis, B. J. Parsons, G. O. Phillips, E. J. Land and A. J. Swallow in "5th Tihany Symposium on Radiation Chemistry" published by the Hungarian Academy of Sciences, (1982),p291-298. The acid-base and redox properties of the one-electron reduced forms of lumichrome derivatives in aqueous solution; P. F. Heelis, B. J. Parsons, G. O. Phillips, E. J. Land and A. J. Swallow in "Proceedings of the Seventh International Congress of Radiation Research", (1983), edited by J. J. Broerse, published by M. Nijhoff, p A4-13. A laser flash photolysis and pulse radiolysis study of amiloride in aqueous and alcoholic solution. H. I. Hamoudi, P. F. Heelis, R. A. Jones. S. Navaratnam, B. J. Parsons, G. O. Phillips, M. J. Vandenburg and W. J. C. Currie,Photochem.Photobiol.(1984),40,35-39. A laser flash photolysis study of the triplet states of lumichromes (1984) by P. F. Heelis and G. O. Phillips in "Flavin and flavoproteins" edited R. C. Bray, P. C. Engel. S. G. Mayhew, published by Walter de Grayter and Co., Berlin,p25-28. A laser flash photolysis study of the triplet states of lumichromes, P. F. Heelis and G. O. Phillips, J. Phys. Chem., (1985), 89, 770-774. Pulse radiolysis study of the effect of pH on the one-electron reduction potentials of lumichrome derivatives, P. F. Heelis, B. J. Parsons, G. O. Phillips, E. J. Land and A. J. Swallow, J.Chem.Soc.Faraday.Trans.I., (1985), 81, 1225-1235. A laser flash photolysis study of the photoreduction of the lumiflavin triplet state, P. F. Heelis, M.De la Rosa and G. O. Phillips. Photobiochem. Photobiophys., (1985), 9, 57-63. One-electron oxidation of the flavin triplet state as studied by laser flash photolysis, P. F. Heelis, B. J. Parsons, B. Thomas and G. O. Phillips, J.Chem.Soc., Chem.Comm., 1985, 954-955. One-electron oxidation of flavins. A flash photolysis and pulse radiolysis study, P. F. Heelis, B. J. Parsons, G. O. Phillips and A. J. Swallow, J.Phys.Chem., (1986), 90, 6833-6836. Photochemical properties of E.Coli DNA photolyase. A flash photolysis study, P. F. Heelis and A. Sancar, Biochem., (1986), 25, 8163-8166. Purification of the yeast PHR1 photolyase from E. Coli. Overproducing strain and characterisation of the intrinsic chromophores of the enzyme. G. B. Sancar, F. W. Smith and P. F. Heelis, J.Biol.Chem., (1987), 262, 15457-15465. The active form of E. Coli DNA photolyase contains a fully reduced flavin and not a flavin radical, both in vivo and in vitro. G. Payne, P. F. Heelis, B. R. Bohrs and A. Sancar. Biochem., (1987), 26, 7121-7127. Flavin-mediated hydrogen peroxide production by biological and chemical photosystems. M. A. De la Rosa, P. F. Heelis, K. K. Rao and D. O. Hall in Flavins and Flavoproteins (1987), edited by D. E. Edmondson and D. B. McCormick, published by Walter de Gruyter and Co., Berlin, p 597-600. Spectral studies on hydrogen bonded alloxazines, J. Koziol, M. M. Szafran and P. F. Heelis, ibid, 1987, p 287-290. Photochemical properties of E. Coli, DNA photolyase: Selective photodecomposition of the second chromophore, P. F. Heelis, G. Payne and A. Sancar. Biochem. 1987, 27, 4634-4640. One-electron oxidation of lumichromes: A flash photolysis and pulse radiolysis study, P. F. Heelis, B. J. Parsons, G. O. Phillips and A. J. Swallow. J.Phys.Chem. 1989 93,4017-4022. One-electron reduction of 5-deazalumiflavin in aqueous solution: A pulse radiolysis study. P. F. Heelis, B. J. Parsons, G. O. Phillips and A. J. Swallow. Int.J.Radiat.Biol., 1989,55,557-562. Effects of the molecular environment on some spectroscopic properties of blepharisma photoreceptor pigment. F. Lenci, F. Ghetti, D. Gioffre, V. Passarelli, P. F. Heelis, B. Thomas, G. O. Phillips and Pill-Soon Song. J.Photochem.Photobiol., 1989,B:Biology,3,449-453. Flavins in liposomes -anomalous effects at high pigment concentrations.P.F.Heelis,G.O.Phillips,F.Lenci,G.Collembetti.,Photochem.Photobiol.1989,49,361-362. Doublet-Quartet intersystem crossing of flavin radical in DNA photolyase.T.Okamura,A.Sancar,P.F.Heelis,Y.Hirata and N.Mataga.J.Am.Chem.Soc.1989,111,5967. Hydrogen bonding and phototautomerism of 3 methyl-lumichrome . M.M.Szafran,J.Koziol and P.F.Heelis.1989,Photochem.Photobiol.1990,52,353-360. Excited state properties of Escherichia Coli DNA photolyase in the picosecond to millisecond range.P.F.Heelis,T.Okamura and A.Sancar.Biochem.1990,29,5694. A pulse radiolysis study of the one-electron oxidation and reduction of 5,10-methenyltetrahydrofolate. P. F. Heelis, B. J. Parsons, G. O. Phillips and A. J. Swallow. Photochem.Photobiol.1991,53,21-23. Fluorescence spectra of crystalline alloxazine and its methyl derivatives.M.M.Szafran,J.Koziol and P.F.Heelis in "Flavin and flavoproteins" published by Walter de Grayter and Co., Berlin,1990 . Picosecond Laser Photolysis studies on the photorepair of pyrimidine dimers by DNA photolyase 1.Laser photolysis of photolyase-2-deoxyuridine dinucleotide photodimer complex.T.Okamura,A.Sancar,P.F.Heelis,T.P.Begley,Y.Hirata and N.Mataga.J.Biol.Chem.(1991) 113,3143-3145. One-electron reduction of 8-hydroxy-5-deazaisoalloxazine in aqueous solution:a pulse radiolysis study.P.F.Heelis, B.J.Parsons and A.J.Swallow, Int.J.Radiat.Biol.1991,59,611-616. Active site of DNA photolyase:Tryptophan-306 is the intrinsic Hydrogen atom donor essential for flavin Radical Photoreduction and DNA repair in vitro,Y.F.Li,P.F.Heelis and A.Sancar,Biochem.1991,30,6322-6329 Determination of rates and yields of interchromophore energy transfer and intermolecular electron transfer in E.Coli DNA photolyase by time resolved fluorescence and absorption spectroscopy.S-T.Kim, P.F.Heelis, T.Okamura, Y.Hirata, N.Mataga and A.Sancar, Biochemistry (1991),30,11262-11270. The effect of hydrogen bonding on the electron transfer reactions of excited triplet and singlet flavins.P.F.Heelis and A.Koziolowa.J.Photochem.Photobiol.1991,11,365-370 Splitting of cyclobutane thymine dimers by radiolysis and its relevance to enzymatic photoreactivation.P.F.Heelis,D.Deeble,S-T.Kim and A.Sancar.Int.J.Radiat.Biol.(1992) 62 137-143. A laser flash photolysis study of the triplet states of the red and blue forms of Blepharisma japonicum pigment, F.Ghetti, G.Checcucci, F.Lenci and P.F.Heelis, J.Photochem.Photobiol. (1992),13, 315-321 Energy transfer (Deazaflavin -FADH2) and electron transfer (FADH2-T<>T) kinetics in Anacystic Nidulans Photolyase S-T.Kim, P.F.Heelis, and A.Sancar, Biochemistry (1992), 31, 11244-11248 Detection of radiacal ion intermediates in flavin-sensitised Pyrimidine dimer splitting, P.F.Heelis, R.F.Hartman and S.D.Rose, Photochem.Photobiol.(1993) 57, 442-446 Detection of the excited singlet state of a deprotonated reduced flavin, P.F.Heelis, R.F.Hartman and S.D.Rose, Photochem.Photobiol. (1993) 57, 1053-55 Excited quartet states in DNA photolyase enzymes., P.F.Heelis, A.Sancar, and T.Okamura, J.Photochem. Photobiol. (1993) 387-390 The photoenzymic repair of UV damaged DNA, P.F.Heelis, Medicine, Biologie, Environment, (1993) 21, 517-525 Detection of a Reduced Flavin Triplet State in Free Flavins and DNA Photolyase, P F. Heelis, C A.Rowley-Williams, R. F. Hartman and SD. Rose, J.Photochem.Photobiol. 23, 1994, 155-159 Laser flash photolysis studies on an intermediate in the repair of pyrimidine dimers by DNA photolyase, M.Volk, S-T.Kim, P.F.Heelis, M.E.Michel-Beyerle, A.Sancar, J.Am.Chem.Soc. 116, 3115, 1994 Low temperature electron paramagnetic resonance studies reveal the structure of Thymine dimer radical anion, I D. Podmore, P F. Heelis, M C. R. Symons and A. Pezeshk, Chemical Communications, 1005 1994. One-Electron Reduction of 1,5-Dihydroflavins in Aqueous Solution: A Pulse Radiolysis Study, P.F Heelis and B.J Parsons, Chemical Communications, 793, 1994 Acid-Base and Redox Properties of Blepharismin Photoreceptor Pigments. A Pulse Radiolysis and Flash Photolysis Study, P.F. Heelis, B.J. Parsons, F. Ghetti, F. Lenci, C.A.Rowley-Williams, S. Naman, S. Navaratnam. J.Photochem.Photobiol, 1994, 24, 41-45 A photoaddition of alcohols to flavins in the presence of EDTA. Paul F. Heelis, Rosemarie F. Hartman and Seth D. Rose, Tetrahedron Letters, 1994, 33, 6053-6056. A PM3 study of the effect of conformation on the enthalpy of splitting of cyclobutane type pyrimidine dimers. P.F.Heelis, J.Mol.Modelling, 1995, 1, 18-21 Electronic energy transfer in DNA photolyase; A molecular orbital study, P. F. Heelis, J.Photochem.Photobiol., 1996 in Press Spectral and redox properties of benzodipteridine. A pulse radiolysis, laser flash photolysis and semi-empirical molecular orbital study, P.F.Heelis, B.J.Parsons and Y.Yano, J.Chem.Soc. Perkin 2, in press, 1996, The photoenzymic repair of the DNA 6-4 photoproduct - a density functional theory and semi-empirical study, P F. Heelis and S. Liu, J.Am.Chem.Soc, in press 1997 Thermal decomposition of Di-Tertiarybutyl Selenide and Dimethylzinc in an Metal-Organic Vapour Phase Epitaxy Reactor, G.H.Fan, T.L.Ng, P.F.Heelis, J.O.Williams and A.C.Wright, D.F.Foster and D.J.Coleman-Hamilton, J.Cryst.Growth, in press, 1996 Electron addition to thymine dimers and related compounds:A mimic of natural repair, A.Pezeshk, I.D.Podmore, P.F.Heelis and M.C.R.Symons, J.Phys.Chem. in press 1996 Back to the Int.J.Sci. Home page