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Education. Ph.D. in Photochemistry 1978, B.Sc. (Hons) Chemistry, 1974 (Salford University, UK) Position. Reader in Chemistry School of Science and Technology The North East Wales Institute, Mold Rd, Wrexham, LL11 2AW, UK Research interests
- Photochemistry, Photobiology, Radiation Chemistry, DNA repair
enzymes, Drug induced phototoxicity, Molecular modelling Grants awarded
from SERC, NATO, The Royal Society, The British Council,
Burroughs-Wellcome, Nuffield Foundation, European Community, The
Wellcome Trust. Invited speaker at
1997 European Society of Photobiology meeting, Italy; 18th
International Conference on Photochemistry, Warsaw; 1996 Gordon
Research Conference on Electron Transfer; 1996 International
Photobiology meeting Vienna; 1995 Symposium on Physical Organic
Chemistry, Poznan, Poland; 1994 French Photobiology Annual
Meeting; 1993 Italian Photobiology Annual Meeting (Plenary
lecture); Secretary to organising committee for the 1995 European
Society for photobiology, Cambridge. Membership of societies. American Society for Photobiology European Photochemical Association British Photobiological Society European Society of Photobiology Reviews The photophysical and photochemical properties
of flavins (isoalloxazines) P.F. Heelis, Chemical Society Reviews
(1982), 112, 15. The Photochemistry of flavins, P. F. Heelis,
(1991 ) in "Chemistry and biochemistry of
flavoenzymes", edited by F. Muller,pp 171 published by
C.R.C. Press. The photorepair of Pyrimidine dimers by DNA
photolyase and model systems, P.F.Heelis, S-T.Kim, T.Okamura, and
A.Sancar J.Photochem. Photobiol. (1993)17, 219-228 The photoenzymic repair of DNA: a chemist's
perspective, Paul F. Heelis, Rosemarie F. Hartman and Seth D.
Rose, Chemical Society Reviews, 1995, p289 Energy and Electron Transfer Processes in
Flavoprotein-Mediated DNA Repair, Paul F. Heelis, Rosemarie F.
Hartman and Seth D. Rose, J.Photochem. Photobiol.A. 1996, 95,
89-98 The role of Tryptophans in substrate binding
and catalysis by DNA photolyase, S-T, Kim, P.F.Heelis and
A.Sancar, Methods in Enzymology, 1995, 258, 319-343. Research Articles A laser photolysis study of the nature of
flavin mononucleotide triplet states and the reaction of the
neutral form with amino acids; P. F. Heelis, B. J. Parsons, G. O.
Phillips and J. F. McKellar. Photochem.Photobiol., (1978), 28,
169-173. The photoreduction of flavins by amino acids
and EDTA. A continuous and flash photolysis study; P. F. Heelis,
B. J. Parsons, G. O. Phillips and J. F. McKellar, Ibid., (1979),
30, 343-347. Flavin pigments embedded in lipid matricies: A
spectroscopic and photochemical investigation. P. F. Heelis, B.
J. Parsons, G. O. Phillips, C. Barghigiani, G. Colombetti, F.
Lenci and J. F. McKellar, Ibid. (1979), 30, 507-512. The pH dependence of the reactions of the
flavin triplet states with amino acids. A laser flash photolysis
study; P. F. Heelis, B. J. Parsons and G. O. Phillips,
Biochim.Biophys.Acta., (1979), 587, 455-462. The photoreduction of flavins - a laser flash
photolysis study; P. F. Heelis and G. O. Phillips.
Photobiochemistry and Photobiophysics, (1979), 1, 63-70. The photodegradation of formylmethylflavin - a
continuous and flash photolysis study; P. F. Heelis, G. O.
Phillips, I. Ahmad and H.D.C. Rapson, Photobiochemistry and
Photobiophysics (1979), 1, 125-130. The alkaline hydrolysis of formyl-methyl
flavin - a kinetic and analytical study; I. Ahmad, H.D.C.Rapson,
P. F. Heelis, G. O. Phillips, J.Org.Chem. (1980), 45, 171-176. The stigma of Euglena gracilis - an
investigation for the possible occurrence of caroteno proteins
and nucleic acids; D. V. Heelis, P. F. Heelis, G. O. Phillips,
Cytobios (1980), 29, 135-143. The flavin sensitised photooxidation of
ascorbic acid - a continuous and flash photolysis study; P. F.
Heelis, B. J. Parsons, G. O. Phillips and J. F. McKellar.
Photochem.Photobiol. (1981), 33, 7-13. Does the stigma of Euglena Gracilis play an
active role in the photoreception process of this organism? A
photochemical investigation of isolated stigmata, D. V. Heelis,
P. F. Heelis, F. Bradshaw and G. O. Phillips.
Photobiochem.Photobiophys., (1981), 3, 77-81. The one-electron reduction of lumichrome and
its methyl derivatives in aqueous solution: A pulse radiolysis
study; P. F. Heelis, B. J. Parsons, G. O. Phillips, E. J. Land
and A. J. Swallow, J. Phys. Chem. (1982), 86, 5169-5174. The acid-base and redox properties of the
one-electron reduced forms of lumichrome derivatives in aqueous
solution; P. F. Heelis, B. J. Parsons, G. O. Phillips, E. J. Land
and A. J. Swallow in "5th Tihany Symposium on Radiation
Chemistry" published by the Hungarian Academy of Sciences,
(1982),p291-298. The acid-base and redox properties of the
one-electron reduced forms of lumichrome derivatives in aqueous
solution; P. F. Heelis, B. J. Parsons, G. O. Phillips, E. J. Land
and A. J. Swallow in "Proceedings of the Seventh
International Congress of Radiation Research", (1983),
edited by J. J. Broerse, published by M. Nijhoff, p A4-13. A laser flash photolysis and pulse radiolysis
study of amiloride in aqueous and alcoholic solution. H. I.
Hamoudi, P. F. Heelis, R. A. Jones. S. Navaratnam, B. J. Parsons,
G. O. Phillips, M. J. Vandenburg and W. J. C.
Currie,Photochem.Photobiol.(1984),40,35-39. A laser flash photolysis study of the triplet
states of lumichromes (1984) by P. F. Heelis and G. O. Phillips
in "Flavin and flavoproteins" edited R. C. Bray, P. C.
Engel. S. G. Mayhew, published by Walter de Grayter and Co.,
Berlin,p25-28. A laser flash photolysis study of the triplet
states of lumichromes, P. F. Heelis and G. O. Phillips, J. Phys.
Chem., (1985), 89, 770-774. Pulse radiolysis study of the effect of pH on
the one-electron reduction potentials of lumichrome derivatives,
P. F. Heelis, B. J. Parsons, G. O. Phillips, E. J. Land and A. J.
Swallow, J.Chem.Soc.Faraday.Trans.I., (1985), 81, 1225-1235. A laser flash photolysis study of the
photoreduction of the lumiflavin triplet state, P. F. Heelis,
M.De la Rosa and G. O. Phillips. Photobiochem. Photobiophys.,
(1985), 9, 57-63. One-electron oxidation of the flavin triplet
state as studied by laser flash photolysis, P. F. Heelis, B. J.
Parsons, B. Thomas and G. O. Phillips, J.Chem.Soc., Chem.Comm.,
1985, 954-955. One-electron oxidation of flavins. A flash
photolysis and pulse radiolysis study, P. F. Heelis, B. J.
Parsons, G. O. Phillips and A. J. Swallow, J.Phys.Chem., (1986),
90, 6833-6836. Photochemical properties of E.Coli DNA
photolyase. A flash photolysis study, P. F. Heelis and A. Sancar,
Biochem., (1986), 25, 8163-8166. Purification of the yeast PHR1 photolyase from
E. Coli. Overproducing strain and characterisation of the
intrinsic chromophores of the enzyme. G. B. Sancar, F. W. Smith
and P. F. Heelis, J.Biol.Chem., (1987), 262, 15457-15465. The active form of E. Coli DNA photolyase
contains a fully reduced flavin and not a flavin radical, both in
vivo and in vitro. G. Payne, P. F. Heelis, B. R. Bohrs and A.
Sancar. Biochem., (1987), 26, 7121-7127. Flavin-mediated hydrogen peroxide production
by biological and chemical photosystems. M. A. De la Rosa, P. F.
Heelis, K. K. Rao and D. O. Hall in Flavins and Flavoproteins
(1987), edited by D. E. Edmondson and D. B. McCormick, published
by Walter de Gruyter and Co., Berlin, p 597-600. Spectral studies on hydrogen bonded
alloxazines, J. Koziol, M. M. Szafran and P. F. Heelis, ibid,
1987, p 287-290. Photochemical properties of E. Coli, DNA
photolyase: Selective photodecomposition of the second
chromophore, P. F. Heelis, G. Payne and A. Sancar. Biochem. 1987,
27, 4634-4640. One-electron oxidation of lumichromes: A flash
photolysis and pulse radiolysis study, P. F. Heelis, B. J.
Parsons, G. O. Phillips and A. J. Swallow. J.Phys.Chem. 1989
93,4017-4022. One-electron reduction of 5-deazalumiflavin in
aqueous solution: A pulse radiolysis study. P. F. Heelis, B. J.
Parsons, G. O. Phillips and A. J. Swallow. Int.J.Radiat.Biol.,
1989,55,557-562. Effects of the molecular environment on some
spectroscopic properties of blepharisma photoreceptor pigment. F.
Lenci, F. Ghetti, D. Gioffre, V. Passarelli, P. F. Heelis, B.
Thomas, G. O. Phillips and Pill-Soon Song.
J.Photochem.Photobiol., 1989,B:Biology,3,449-453. Flavins in liposomes -anomalous effects at
high pigment
concentrations.P.F.Heelis,G.O.Phillips,F.Lenci,G.Collembetti.,Photochem.Photobiol.1989,49,361-362.
Doublet-Quartet intersystem crossing of flavin
radical in DNA photolyase.T.Okamura,A.Sancar,P.F.Heelis,Y.Hirata
and N.Mataga.J.Am.Chem.Soc.1989,111,5967. Hydrogen bonding and phototautomerism of 3
methyl-lumichrome . M.M.Szafran,J.Koziol and
P.F.Heelis.1989,Photochem.Photobiol.1990,52,353-360. Excited state properties of Escherichia Coli
DNA photolyase in the picosecond to millisecond
range.P.F.Heelis,T.Okamura and A.Sancar.Biochem.1990,29,5694. A pulse radiolysis study of the one-electron
oxidation and reduction of 5,10-methenyltetrahydrofolate. P. F.
Heelis, B. J. Parsons, G. O. Phillips and A. J. Swallow.
Photochem.Photobiol.1991,53,21-23. Fluorescence spectra of crystalline alloxazine
and its methyl derivatives.M.M.Szafran,J.Koziol and P.F.Heelis in
"Flavin and flavoproteins" published by Walter de
Grayter and Co., Berlin,1990 . Picosecond Laser Photolysis studies on the
photorepair of pyrimidine dimers by DNA photolyase 1.Laser
photolysis of photolyase-2-deoxyuridine dinucleotide photodimer
complex.T.Okamura,A.Sancar,P.F.Heelis,T.P.Begley,Y.Hirata and
N.Mataga.J.Biol.Chem.(1991) 113,3143-3145. One-electron reduction of
8-hydroxy-5-deazaisoalloxazine in aqueous solution:a pulse
radiolysis study.P.F.Heelis, B.J.Parsons and A.J.Swallow,
Int.J.Radiat.Biol.1991,59,611-616. Active site of DNA photolyase:Tryptophan-306
is the intrinsic Hydrogen atom donor essential for flavin Radical
Photoreduction and DNA repair in vitro,Y.F.Li,P.F.Heelis and
A.Sancar,Biochem.1991,30,6322-6329 Determination of rates and yields of
interchromophore energy transfer and intermolecular electron
transfer in E.Coli DNA photolyase by time resolved fluorescence
and absorption spectroscopy.S-T.Kim, P.F.Heelis, T.Okamura,
Y.Hirata, N.Mataga and A.Sancar, Biochemistry
(1991),30,11262-11270. The effect of hydrogen bonding on the electron
transfer reactions of excited triplet and singlet
flavins.P.F.Heelis and
A.Koziolowa.J.Photochem.Photobiol.1991,11,365-370 Splitting of cyclobutane thymine dimers by
radiolysis and its relevance to enzymatic
photoreactivation.P.F.Heelis,D.Deeble,S-T.Kim and
A.Sancar.Int.J.Radiat.Biol.(1992) 62 137-143. A laser flash photolysis study of the triplet
states of the red and blue forms of Blepharisma japonicum
pigment, F.Ghetti, G.Checcucci, F.Lenci and P.F.Heelis,
J.Photochem.Photobiol. (1992),13, 315-321 Energy transfer (Deazaflavin -FADH2) and
electron transfer (FADH2-T<>T) kinetics in Anacystic
Nidulans Photolyase S-T.Kim, P.F.Heelis, and A.Sancar,
Biochemistry (1992), 31, 11244-11248 Detection of radiacal ion intermediates in
flavin-sensitised Pyrimidine dimer splitting, P.F.Heelis,
R.F.Hartman and S.D.Rose, Photochem.Photobiol.(1993) 57, 442-446 Detection of the excited singlet state of a
deprotonated reduced flavin, P.F.Heelis, R.F.Hartman and
S.D.Rose, Photochem.Photobiol. (1993) 57, 1053-55 Excited quartet states in DNA photolyase
enzymes., P.F.Heelis, A.Sancar, and T.Okamura, J.Photochem.
Photobiol. (1993) 387-390 The photoenzymic repair of UV damaged DNA,
P.F.Heelis, Medicine, Biologie, Environment, (1993) 21, 517-525 Detection of a Reduced Flavin Triplet State in
Free Flavins and DNA Photolyase, P F. Heelis, C
A.Rowley-Williams, R. F. Hartman and SD. Rose,
J.Photochem.Photobiol. 23, 1994, 155-159 Laser flash photolysis studies on an
intermediate in the repair of pyrimidine dimers by DNA
photolyase, M.Volk, S-T.Kim, P.F.Heelis, M.E.Michel-Beyerle,
A.Sancar, J.Am.Chem.Soc. 116, 3115, 1994 Low temperature electron paramagnetic
resonance studies reveal the structure of Thymine dimer radical
anion, I D. Podmore, P F. Heelis, M C. R. Symons and A. Pezeshk,
Chemical Communications, 1005 1994. One-Electron Reduction of 1,5-Dihydroflavins
in Aqueous Solution: A Pulse Radiolysis Study, P.F Heelis and B.J
Parsons, Chemical Communications, 793, 1994 Acid-Base and Redox Properties of Blepharismin
Photoreceptor Pigments. A Pulse Radiolysis and Flash Photolysis
Study, P.F. Heelis, B.J. Parsons, F. Ghetti, F. Lenci,
C.A.Rowley-Williams, S. Naman, S. Navaratnam.
J.Photochem.Photobiol, 1994, 24, 41-45 A photoaddition of alcohols to flavins in the
presence of EDTA. Paul F. Heelis, Rosemarie F. Hartman and Seth
D. Rose, Tetrahedron Letters, 1994, 33, 6053-6056. A PM3 study of the effect of conformation on
the enthalpy of splitting of cyclobutane type pyrimidine dimers.
P.F.Heelis, J.Mol.Modelling, 1995, 1, 18-21 Electronic energy transfer in DNA photolyase;
A molecular orbital study, P. F. Heelis, J.Photochem.Photobiol.,
1996 in Press Spectral and redox properties of
benzodipteridine. A pulse radiolysis, laser flash photolysis and
semi-empirical molecular orbital study, P.F.Heelis,
B.J.Parsons and Y.Yano, J.Chem.Soc. Perkin 2, in press, 1996, The photoenzymic repair of the DNA 6-4
photoproduct - a density functional theory and semi-empirical
study, P F. Heelis and S.
Liu, J.Am.Chem.Soc, in press 1997 Thermal decomposition of Di-Tertiarybutyl
Selenide and Dimethylzinc in an Metal-Organic Vapour Phase
Epitaxy Reactor, G.H.Fan, T.L.Ng, P.F.Heelis, J.O.Williams and
A.C.Wright, D.F.Foster and D.J.Coleman-Hamilton, J.Cryst.Growth,
in press, 1996 Electron addition to thymine dimers and related compounds:A mimic of natural repair, A.Pezeshk, I.D.Podmore, P.F.Heelis and M.C.R.Symons, J.Phys.Chem. in press 1996 |
